A serial killer is on the loose in Boston. The victims are killed in a particularly nasty way, the killer obviously has medical knowledge and has been dubbed "the Surgeon" by the media. Detective Thomas Moore and his partner Rizzoli of the Boston Homicide Unit have discovered something that makes this case even more chilling. Years ago in Savannah a serial killer murdered in exactly the same way. He was finally stopped by his last victim who shot him as he tried to cut her. That last victim is Dr Catherine Cordell, who now works as a cardiac surgeon at one of Boston's prestigious hospitals. As the murders continue, it becomes obvious that the killer is drawing closer and closer to Dr Cordell who only person who can help the police catch this copycat killer. Or is it a copycat?